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Molecular Diagnostic Probe for laboratories
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wd123E22
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PML / RARA融合探针
◆产品优势
1.Fleetness:组织探针杂交时间:2小时。细胞探针杂交时间:1小时。
2.准确性:减少非特异性背景染色(染色)。增加难以检测的样品检出率
3.可重复性:不同的实验室测试结果具有高度可重复性。
◆探针描述
PML / RARA基因融合探针使用橙红染料标记的PML探针和绿色染料标记的RARA探针,两种探针可通过原位杂交与靶标检测位点结合。通常(PML / RARA基因不融合),在荧光显微镜下显示两个橙色和两个绿色信号。当存在融合基因时,重构绿色和橙色信号以形成黄色融合信号。
◆临床意义
PML / RARA融合基因是急性早幼粒细胞白血病(APL)的特征性标志物。PML / RARA融合蛋白通过显性负抑制抑制早幼粒细胞的分化和成熟,从而阻断细胞分化并导致持续增殖。全反式维甲酸(ATRA)和三氧化二砷均能降解PML / RARA融合蛋白,恢复野生型PML和RARA基因的功能,减轻基因转录的抑制,诱导细胞分化和凋亡,从而有效治疗APL。ATRA联合化疗可以使APL的完全缓解率达到90%~95%,超过70%的患者可以长期存活。
◆尺寸规格
◆参考
Abe S,et al。(2008)Cancer Genet and Cytogenet 184:44-7。
Sanz MA,et al。(2009)Blood 113:1875-91实验室分子诊断探针
网站:http://www.health-carebiotech.com/molecular-diagnostic-probe/
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Thanks for the blog.Thanks Again. Awesome
MerlLamoth edit at 2019-01-18 09:15:27
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Thank You For Amazing Information Admin Please Check My Article On
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